Bani'aadamka ROS1 Fusion Hid is beddelka

Sharaxaad Gaaban:

Xirmadan waxa loo isticmaalaa in lagu ogaado in vitro lagu ogaanayo tayada 14ka nooc ee isku-bedelka hidda-wadaha ROS1 ee shaybaarada kansarka sambabada ee unugyada aan-yaraha ahayn (Shaxda 1).Natiijooyinka baaritaanka waxaa loogu talagalay tixraaca bukaan-socodka oo keliya mana aha in loo isticmaalo saldhigga keliya ee daaweynta gaarka ah ee bukaanka.


Faahfaahinta Alaabta

Tags Product

Magaca alaabta

HWTS-TM009-Human ROS1 Qalabka Ogaanshaha Isku-beddelka Hiddaha (Fluorescence PCR)

Shahaado

CE

Epidemiology

ROS1 waa transmembrane tyrosine kinase ee qoyska reseptors insulin.Hidde-sidayaasha fiyuuska ee ROS1 ayaa la xaqiijiyay inuu yahay hidde kale oo muhiim ah oo aan ahayn unugga yar ee kansarka sambabada.Sida wakiil ka mid ah nooc-hoosaadka molecular-ka cusub ee gaarka ah, dhacdooyinka hidda-wadaha isku-dhafka ROS1 ee NSCLC Qiyaastii 1% ilaa 2% ROS1 waxay inta badan maraysaa dib-u-habaynta hidda-wadaha ee 32, 34, 35 iyo 36. EZR, SLC34A2, iyo SDC4, waxay sii wadi doontaa inay dhaqaajiso gobolka ROS1 tyrosine kinase.ROS1 kinase aan caadi ahayn oo firfircooni waxay dhaqaajin kartaa dariiqyada calaamadaha hoose sida RAS/MAPK/ERK, PI3K/Akt/mTOR, iyo JAK3/STAT3, taas oo ka qayb qaadanaysa fidinta, kala soocida iyo dheef-shiid kiimikaadka unugyada burooyinka, oo keena kansar.Isku-beddelka ROS1, CD74-ROS1 wuxuu xisaabiyaa qiyaastii 42%, EZR waxay xisaabisaa qiyaastii 15%, SLC34A2 waxay xisaabisaa qiyaastii 12%, iyo SDC4 waxay xisaabisaa qiyaastii 7%.Daraasaduhu waxay muujiyeen in goobta ATP-ku-xiran ee domain catalytic ee ROS1 kinase iyo goobta ATP ee ALK kinase ay leeyihiin isku-dhafan ilaa 77%, sidaa darteed ALK tyrosine kinase yar yar oo ah inhibitor crizotinib iyo wixii la mid ah waxay leeyihiin saameyn daaweyn oo muuqda. daawaynta NSCLC oo leh isku beddelka fiyuuska ee ROS1.Sidaa darteed, ogaanshaha isbeddellada isku-dhafka ROS1 waa aasaaska iyo saldhigga hagidda isticmaalka dawooyinka crizotinib.

Kanaalka

FAM Reaction Buffer 1, 2, 3 iyo 4
VIC(HEX) Reaction Buffer 4

Qiyaasaha Farsamada

Kaydinta

≤-18℃

Nolosha shelf

9 bilood

Nooca Tuunada

nudaha cudurrada ee paraffin-ku-xidhan ama muunado la jarjaray

CV

5.0%

Ct

≤38

LoD

Qalabkani waxa uu ogaan karaa isku-bedelka fiyuuska ilaa 20 nuqul.

Qalabka lagu dabaqi karo:

Nidaamyada noolaha ee la dabaqay 7500 Nidaamyada PCR-waqtiga-dhabta ahNidaamyada noolaha ee la dabaqay 7500 Nidaamyada PCR-waqtiga-dhabta ah ee degdegga ah

SLAN ®-96P Nidaamyada PCR-waqtiga-dhabta ah

QuantStudio™ 5 Nidaamyada PCR-waqtiga-dhabta ah

LightCycler®480 Nidaamka PCR-waqtiga-dhabta ah

LineGene 9600 Plus-Waqtiga dhabta ah ee PCR Nidaamka ogaanshaha

MA-6000-waqtiga-dhabta ah ee cabbirka kulaylka wareegga

BioRad CFX96 Nidaamka PCR-waqtiga-dhabta ah

BioRad CFX Opus 96 Nidaamka PCR-waqtiga-dhabta ah

Socodka Shaqada

Soo saarista lagu taliyay: Qalabka RNeasy FFPE (73504) ee QIAGEN, Qaybta Unugyada Paraffin Embedded Tissue Kit (DP439) ee Tiangen Biotech(Beijing) Co., Ltd.


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