Methylated Human NDRG4/SEPT9/SFRP2/BMP3/SDC2 Hid

Sharaxaad Gaaban:

Qalabka waxaa loogu talagalay in lagu ogaado tayada tayada leh ee methylated NDRG4/SEPT9/SFRP2/BMP3/SDC2 ee unugyada xiidmaha ee xiidmaha ee muunadaha saxarada aadanaha.


Faahfaahinta Alaabta

Tags Product

Magaca alaabta

HWTS-OT077-Methylated Human NDRG4/SEPT9/SFRP2/BMP3/SDC2 Qalabka ogaanshaha Hiddaha (Pluorescence PCR)

Shahaado

CE

Epidemiology

Dadka qaangaarka ah, in ka badan 10 8 unugyada epithelial xiidmaha ayaa ka soo dhaca derbiga mindhicirka maalin kasta, waxaana laga soo saaraa saxarada iyada oo loo marayo peristalsis weyn ee mindhicirka.Sababtoo ah unugyada burooyinka waxay u badan tahay inay ka dhacaan mindhicirka mindhicirka ee faafitaanka aan caadiga ahayn, saxarada bukaanka burooyinka mindhicirka waxay ka kooban yihiin unugyo badan oo buka iyo qaybaha unugyada aan caadiga ahayn, taas oo ah saldhigga alaabta lagu ogaanayo saxarada deggan.Daraasaduhu waxay ogaadeen in wax ka beddelka methylation ee dhiirrigeliyeyaasha hidda-wadaha ay tahay dhacdo hore oo ku dhacda tumorigenesis, iyo walxaha hidde-sidaha ee laga helo muunadaha saxarada ee bukaannada kansarka mindhicirka waxay ka tarjumayaan jiritaanka kansarka mindhicirka hore.

NDRG4, oo sidoo kale loo yaqaan SMAP-8 iyo BDM1, waa mid ka mid ah afarta xubnood ee qoyska hidda-wadaha NDRG1-4 (NDRG1-4), kaas oo la muujiyay inay la xiriiraan kororka unugyada, kala duwanaanta, horumarka iyo walbahaarka.Waxaa la xaqiijiyay in NDRG4 methylation uu yahay biomarker suurtagal ah oo loogu talagalay ogaanshaha aan fiicneyn ee kansarka mindhicirka ee muunadaha saxarada.

SEPT9 waa xubin ka mid ah qoyska hidde-sideyaasha Septin, kaas oo ka kooban ugu yaraan 13 hidde-side kuwaas oo soo koobaya domain GTPase ee la ilaaliyo kaas oo xidhi kara borotiinnada la xidhiidha cytoskeleton, oo la xidhiidha qaybinta unugyada iyo tumorigenesis.Daraasaduhu waxay ogaadeen in hidde-sideyaasha methylated Septin9 ay si gaar ah u korodhay shaybaarrada saxarada ee bukaannada qaba kansarka mindhicirka.

Borotiinnada laxiriira sirta ah ee frizzled (sFRPs) waa borotiinno milmi kara kuwaas oo ah fasalka Wnt pathway antagonists sababtoo ah qaabdhismeedkooda sare ee qaboojiyaha frizzled (Fz) ee calaamadaha Wnt.Dhaqdhaqaaq la'aanta hidda-wadaha SFRP waxay keentaa firfircooni aan la xakameynin ee calaamadaha Wnt ee la xidhiidha kansarka mindhicirka.Waqtigan xaadirka ah, SFRP2 methylation ee saxarada waxaa loo isticmaali karaa biomarker-ka-soo-baxa ah ee ogaanshaha kansarka mindhicirka.

BMP3 waa xubin ka mid ah qoyska weyn ee TGF-B oo sidaas awgeed waxay door muhiim ah ka ciyaartaa korriinka uurjiifka iyada oo kicinaysa oo qaabaynaysa samaynta lafaha hore.BMP3 waa hypermethylated ee kansarka mindhicirka waxaana loo isticmaali karaa calaamad muhiim ah oo buro ah.

SDC2 waa unug oogada heparan sulfate proteoglycan oo ku lug leh nidaaminta habab badan oo nafsiyeed iyo cudur.Hababka jireed waxaa ka mid ah kororka unugyada, kala duwanaanta, adhesion, ururka cytoskeletal, hijrada, bogsashada boogta, isgaarsiinta unugyada-matrixka, angiogenesis;Hababka cilmu-nafsiga waxaa ka mid ah bararka iyo kansarka.Heerka methylation ee hiddo-wadaha SDC2 ee unugyada kansarka mindhicirka ayaa aad uga sarreeya kan unugyada caadiga ah.

Kanaalka

Dareeraha falcelinta A

VIC/HEX hidda-wadaha NDRG4 methylated
ROX hiddo-wadaha SEPT9 methylated
CY5 xakamaynta gudaha

Dareeraha falcelinta B

VIC/HEX hiddo-wadaha SFRP2 methylated
ROX hiddo-wadaha BMP3 methylated
FAM hiddo-wadaha methylated SDC2
CY5 xakamaynta gudaha

Tafsiir

Gene

Kanaalka ishaarka

Ct Qiimaha

Tafsiir

NDRG4

VIC (HEX)

Qiimaha Ct≤38

NDRG4 togan

Qiimaha Ct>38 ama unde

NDRG4 xun

SEPT9

ROX

Qiimaha Ct≤38

SEPT9 togan

Qiimaha Ct>38 ama unde

SEPT9 xun

SFRP2

VIC (HEX)

Qiimaha Ct≤38

SFRP2 togan

Qiimaha Ct>38 ama unde

SFRP2 taban

Qiyaasaha Farsamada

Kaydinta Dareeraha: ≤-18℃
Nolosha shelf 9 bilood
Nooca Tuunada Tusaalaha Saxarada
CV ≤5.0%
Gaar ahaan Ma jiro fal-celin isdhaafsi ah oo leh kansarka beerka, kansarka bile duct kansarka, kansarka tayroodhka iyo kansarka sanbabada
Qalabka lagu dabaqi karo QuantStudio ®5 Nidaamyada PCR-waqtiga-dhabta ah

SLAN-96P Nidaamyada PCR-Waqtiga-dhabta ah

LightCycler®480 Nidaamka PCR-waqtiga-dhabta ah

LineGene 9600 Plus-Waqtiga dhabta ah ee PCR Nidaamka ogaanshaha

MA-6000-waqtiga-dhabta ah ee cabbirka kulaylka wareegga

Socodka Shaqada

Soo saarista lagu taliyay: Macro & Micro-Tijaabo Viral DNA/RNA Kit (HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) 3006).


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