Bani'aadamka EML4-ALK Fusion Hid is beddelka

Sharaxaad Gaaban:

Qalabkan waxa loo isticmaalaa in si tayo leh lagu ogaado 12 nooc oo beddelaad ah oo EML4-ALK ah hiddo-wadaha isku dhafka ah ee muunado ee bukaannada kansarka sambabada ee unugyada aan yarayn ee gudaha vitro.Natiijooyinka baaritaanka waxaa loogu talagalay tixraaca bukaan-socodka oo keliya mana aha in loo isticmaalo saldhigga keliya ee daaweynta gaarka ah ee bukaanka.Dhakhaatiirtu waa inay sameeyaan go'aanno dhammaystiran oo ku saabsan natiijooyinka baaritaanka oo ku saleysan arrimo ay ka mid yihiin xaaladda bukaanka, calaamadaha daroogada, jawaabta daaweynta, iyo tilmaamayaasha kale ee baaritaanka sheybaarka.


Faahfaahinta Alaabta

Tags Product

Magaca alaabta

HWTS-TM006-Human EML4-ALK Xirmada ogaanshaha isku-beddelka Hiddaha (Fluorescence PCR)

Shahaado

CE

Epidemiology

Qalabkan waxa loo isticmaalaa in si tayo leh lagu ogaado 12 nooc oo beddelaad ah oo EML4-ALK ah hiddo-wadaha fiyuuska ee muunado bukaannada kansarka sambabada ee unugyada aan-yarayn ee bini'aadamka ku jira.Natiijooyinka baaritaanka waxaa loogu talagalay tixraaca bukaan-socodka oo keliya mana aha in loo isticmaalo saldhigga keliya ee daaweynta gaarka ah ee bukaanka.Dhakhaatiirtu waa inay sameeyaan go'aanno dhammaystiran oo ku saabsan natiijooyinka baaritaanka oo ku saleysan arrimo ay ka mid yihiin xaaladda bukaanka, calaamadaha daroogada, jawaabta daaweynta, iyo tilmaamayaasha kale ee baaritaanka sheybaarka.Kansarka sambabada waa buro halis ah oo ugu caansan aduunka oo dhan, iyo 80% ~ 85% kiisaska waa kansarka sambabada unugyada aan yarayn (NSCLC).Fiyuuska hidda-wadaha ee echinoderm microtubule-ku-xiran borotiin-sida 4 (EML4) iyo anaplastic lymphoma kinase (ALK) waa bartilmaameed cusub oo NSCLC, EML4 iyo ALK waxay u kala horreeyaan gudaha bini'aadamka P21 iyo P23 bands ee koromosoom 2 waxaana loo kala saaraa qiyaastii 12.7 malyan oo saldhig.Ugu yaraan 20 nooc oo kala duwanaansho ah ayaa la helay, kuwaas oo ay ka mid yihiin 12-ka fusion mutants ee Jadwalka 1 ku jira ay caadi yihiin, halkaas oo mutant 1 (E13; A20) uu yahay midka ugu badan, oo ay ku xigto mutants 3a iyo 3b (E6; A20), xisaabinta qiyaastii. 33% iyo 29% bukaanada qaba EML4-ALK fusion gene NSCLC, siday u kala horreeyaan.Kahortagayaasha ALK ee uu matalo Crizotinib waa dawooyin la bar tilmaameedsado yar-yar oo loo sameeyay isku-dhafka hidda-wadaha ALK.Iyadoo la xakameynayo dhaqdhaqaaqa gobolka ALK tyrosine kinase, oo xannibaya dariiqyada calaamadaha aan caadiga ahayn ee hoose, taas oo joojinaysa koritaanka unugyada burooyinka, si loo gaaro daawaynta la beegsanayo ee burooyinka.Daraasadaha kiliinikada ayaa muujiyay in Crizotinib ay leedahay heer wax ku ool ah oo ka badan 61% bukaanada leh EML4-ALK mutations fusion, halka aysan ku dhawaad ​​​​wax saameyn ah ku yeelan bukaannada duurjoogta ah.Sidaa darteed, ogaanshaha EML4-ALK isu beddelka isku-dhafka ayaa ah aasaaska iyo saldhigga hagidda isticmaalka dawooyinka Crizotinib.

Kanaalka

FAM Celcelis ahaan falcelinta 1, 2
VIC(HEX) Baqdinta falcelinta 2

Qiyaasaha Farsamada

Kaydinta

≤-18℃

Nolosha shelf

9 bilood

Nooca Tuunada

Unugyada cudurrada ee paraffin-ku-xidhan ama muunadaha qaybta

CV

5.0%

Ct

≤38

LoD

Qalabkani waxa uu ogaan karaa isku-bedelka fiyuuska ilaa 20 nuqul.

Qalabka lagu dabaqi karo:

Nidaamyada noolaha ee la dabaqay 7500 Nidaamyada PCR-waqtiga-dhabta ah

Nidaamyada noolaha ee la dabaqay 7500 Nidaamyada PCR-waqtiga-dhabta ah ee degdegga ah

SLAN ®-96P Nidaamyada PCR-waqtiga-dhabta ah

QuantStudio™ 5 Nidaamyada PCR-waqtiga-dhabta ah

LightCycler®480 Nidaamka PCR-waqtiga-dhabta ah

LineGene 9600 Plus-Waqtiga dhabta ah ee PCR Nidaamka ogaanshaha

MA-6000-waqtiga-dhabta ah ee cabbirka kulaylka wareegga

BioRad CFX96 Nidaamka PCR-waqtiga-dhabta ah

BioRad CFX Opus 96 Nidaamka PCR-waqtiga-dhabta ah

Socodka Shaqada

Soo saarista lagu taliyay: Qalabka RNeasy FFPE (73504) ee QIAGEN, Qaybaha Unugyada Paraffin-ku-xidhan Wadarta Qalabka Soosaarida RNA (DP439) ee Tiangen Biotech(Beijing) Co., Ltd.


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